Bulletin of the American Physical Society
2018 Annual Meeting of the APS Mid-Atlantic Section
Volume 63, Number 20
Friday–Sunday, November 9–11, 2018; College Park, Maryland
Session B01: Poster Session (Day 1)
8:00 PM,
Friday, November 9, 2018
Edward St. John
Room: Lounge
Chair: Wendell T. Hill, III, University of Maryland, College Park
Abstract ID: BAPS.2018.MAS.B01.30
Abstract: B01.00030 : Collective dynamics over long time scales and large length scales reveals distinct cell migration phenotypes*
Presenter:
Rachel Lee
(Univ of Maryland-College Park)
Authors:
Rachel Lee
(Univ of Maryland-College Park)
Haicen Yue
(University of California, San Diego)
Christina Stuelten
(National Cancer Institute, National Institutes of Health)
Wouter-Jan Rappel
(University of California, San Diego)
Carole Parent
(National Cancer Institute, National Institutes of Health)
Wolfgang Losert
(Univ of Maryland-College Park)
In this study, we investigate multiple length and time scales in the collective migration of cell sheets and show that particle image velocimetry (PIV) based measurements yield insight into biological mechanisms. Comparing experimental PIV flow fields from migrating cells to the behavior of simulated cell groups, we connect individual cell properties to collective behavior over the millimeter-scale of the cell monolayer. We find that cell migration at the boundary can affect migration within the monolayer without the need to specify large-scale features in the simulations. In addition to tissue-scale trends in collective behavior, migrating cells have localized dynamic features which can change over multiple time scales. We developed a set of measurement techniques to extract multiple features of collective motion, and apply these techniques to both non-malignant and tumorigenic breast epithelial cells.
*This work was supported by the JCM Foundation through an ARCS/MWC Scholar Award to R. Lee. R. Lee and W. Losert acknowledge NSF grant PHY1205965. W. Rappel and H. Yue were supported by NIH Grant No. P01 GM078586 and NSF Grant No. DMS 1309542. This research was supported in part by the Intramural Research Program of the Center for Cancer Research, NCI, National Institutes of Health.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2018.MAS.B01.30
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