Bulletin of the American Physical Society
2018 Annual Meeting of the APS Mid-Atlantic Section
Volume 63, Number 20
Friday–Sunday, November 9–11, 2018; College Park, Maryland
Session B01: Poster Session (Day 1)
8:00 PM,
Friday, November 9, 2018
Edward St. John
Room: Lounge
Chair: Wendell T. Hill, III, University of Maryland, College Park
Abstract ID: BAPS.2018.MAS.B01.31
Abstract: B01.00031 : A Method for the Large-Scale Production of Nanotopographical Surfaces for Cellular Studies*
Presenter:
Matt J Hourwitz
(Univ of Maryland-College Park)
Authors:
Matt J Hourwitz
(Univ of Maryland-College Park)
Xiaoyu Sun
(Rockefeller University)
Eleni M Baker
(Univ of Maryland-College Park)
Sebastian Schmidt
(Univ of Maryland-College Park)
Wolfgang Losert
(Univ of Maryland-College Park)
John T Fourkas
(Univ of Maryland-College Park)
The physical environment of cells impacts their behavior and plays a role in biological processes. Finding ways to mimic in vivo characteristics of cells’ physical surroundings can give a clearer picture of their response to natural textures. We developed a method for fabricating patterns of arbitrary shape and replicating them on a large scale for use in cellular studies. Multiphoton absorption polymerization (MAP), a two-photon lithographic technique, was used to design and fabricate the topographical features. Solvent-assisted nanotransfer molding allowed for the creation of a negative-relief mold made of poly(dimethylsiloxane) (PDMS). Replica molding, with this PDMS mold and a photocurable resin, can reproduce the original pattern made with MAP. The replica nanotopographies can be adapted to fit specific experimental requirements, including surface coating. The patterned films have been shown to be biocompatible. To demonstrate their use, we examined the cytoskeletal arrangement of MCF10A cells on one nanotopographical pattern.
*M. J. Hourwitz acknowledges support from the NCI-UMD Partnership for Integrative Cancer Research. The research was supported by the National Institutes of Health (R01GM085574), as well as the Air Force Office of Scientific Research (FA9550-16-1-0052)
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2018.MAS.B01.31
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