Transdermal Administration of Adenosine and Eosin Y Using Microplasma*

The strong barrier established by the human stratum corneum serves a protective purpose. It also prevents pharmacological compounds from being delivered into the skin. One of the most important functions of transdermal drug delivery is to get beyond the stratum corneum. We used microplasma discharge treatment to overcome this skin barrier. The permeation and retention of Adenosine through the skin of a Yucatan micropig’s skin were investigated using a Franz diffusion cell. HPLC was used to determine the amount of drug that had entered and remained inside the skin layer. We evaluated and compared Adenosine penetration through the treated and untreated skin by microplasma. After the treatment, the depth of penetration was measured using the Eosin Y dye. Microplasma treatment enhanced drug penetration through the epidermal layer of the skin, according to the findings in this study.