Bulletin of the American Physical Society
APS March Meeting 2021
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session S12: Physics of Neural Systems I
11:30 AM–2:30 PM,
Thursday, March 18, 2021
Sponsoring Unit: DBIO
Chair: Andrew Leifer, Princeton University; John Beggs, Indiana Univ - Bloomington
Abstract: S12.00005 : Stimulation-induced long-lasting desynchronization of plastic neuronal networks
12:18 PM–12:30 PM
Peter A. Tass
We study stimulation-induced long-lasting desynchronization in plastic neuronal networks. Our theoretical analysis reveals mechanisms by which stimulation may affect network connectivity and stabilize desired activity patterns. We present a Random Reset stimulation protocol that specifically targets synaptic connections. Remarkably, long-lasting desynchronization is achieved even though the neurons remain partially synchronized during stimulation. In contrast to previous approaches, Random Reset stimulation does not rely on a fine tuning of the stimulation frequency to the pathological synchronous rhythm. This may be advantageous in treating Parkinson’s disease where different pathological rhythms may coexist.
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