Bulletin of the American Physical Society
APS March Meeting 2021
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session S11: Physics of Cytoskeleton Across Scales IV
11:30 AM–2:30 PM,
Thursday, March 18, 2021
Sponsoring Unit: DBIO
Chair: James Liman, Rice Univ; Jing Xu, University of California, Merced
Abstract: S11.00005 : Studying in vitro the effect of actin dynamics on membrane tubes*
12:42 PM–12:54 PM
To address this issue, I use in vitro reconstituted systems with a minimal number of compounds to control the growth of a branched actin sleeve at the surface of preformed tubes. These tubes can be formed using an optically trapped bead. The presence of a tube affects the amplitude of bead fluctuations at long time scale while an actin sleeve surrounding the tube modifies its short time fluctuations. Furthermore, depending on network cohesiveness, actin either entirely or locally stabilise membrane tubes under extension. On a single tube, different tube radii coexist over several minutes, and may provide enough time and curvature geometries for other proteins to act on tube stability.
*Fondation pour la Recherche Médicale FDT201904007966
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