Bulletin of the American Physical Society
APS March Meeting 2021
Volume 66, Number 1
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session L11: Immune Sensing and Response I
8:00 AM–10:36 AM,
Wednesday, March 17, 2021
Sponsoring Unit: DBIO
Chair: Amir Erez, Princeton University
Abstract: L11.00011 : Deep generative selection models of T and B cell receptor repertoires with soNNia
10:24 AM–10:36 AM
(Physics, University of Washington)
Additionally to these functional roles, T and B-cell lymphocytes rely on the diversity of their receptor chains to recognize different pathogens.
The lymphocyte subclasses emerge from common ancestors generated with the same diversity of receptors during selection processes.
I will show how to leverage biophysical models of receptor generation with machine learning models of selection to identify specific sequence features characteristic of functional lymphocyte repertoires and subrepertoires.
Specifically using only repertoire level sequence information, we classify CD4 and CD8 T-cells, find correlations between receptor chains arising during selection and identify T-cells subsets that are targets of pathogenic epitopes.
I also show examples of when linear classifiers do as well as deep methods.
The American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics.
1 Physics Ellipse, College Park, MD 20740-3844
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700