Bulletin of the American Physical Society
APS March Meeting 2021
Volume 66, Number 1
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session L01: Delbruck Prize Symposium
8:00 AM–10:24 AM,
Wednesday, March 17, 2021
Room: 01
Sponsoring
Unit:
DBIO
Chair: Ricard Alert, Princeton University; Cristina Marchetti, University of California, Santa Barbara
Abstract: L01.00004 : Flow, fluctuate and freeze: Epithelial cell sheets as soft active matter*
9:48 AM–10:24 AM
Live
Presenter:
Silke Henkes
(School of Mathematics, University of Bristol)
Author:
Silke Henkes
(School of Mathematics, University of Bristol)
I will start by introducing the simplest useful class of models, active brownian particles (ABPs), which incorporate uncoordinated active crawling over a substrate and mechanical interactions. Using this model, I will show how the extended ’swirly’ velocity fluctuations seen in sheets on a substrate can be understood using a simple model that couples linear elasticity with disordered activity. We are able to quantitatively match experiments using in-vitro corneal epithelial cells. Adding a different source of activity, cell division and apoptosis, to such a model leads to a novel 'self-melting' dense fluid state. I will then directly apply this simple particle-based model to explain the steady-state spiral flow pattern on the mouse cornea.
*BBSRC EASTBIO doctoral training centre
BBSRC BB/N009150/1-2 and BB/N009789/1-2
CPTGA visiting scientist program
NRP Pecre exchange program
EPSRC First Grant EP/M009599/1
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