Bulletin of the American Physical Society
APS March Meeting 2021
Volume 66, Number 1
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session C13: Physics of Biological Active Matter I: Cell Colonies
3:00 PM–5:48 PM,
Monday, March 15, 2021
Sponsoring Units: DBIO DPOLY DSOFT
Chair: Ricard Alert, Princeton University; Joshua Shaevitz, Princeton University
Abstract: C13.00001 : Mechanical behavior of a migrating cell monolayer.
3:00 PM–3:36 PM
(Univ de Lyon)
(Univ de Lyon)
tissue migration by measuring cell velocity, density and cell-substrate interaction force.
We perform migration experiments of Madin-Darby Canine Kidney (MDCK) epithelial cells over a day or more. We observe spontaneous velocity waves, or induce a heterogeneous cell flow around an obstacle to observe cell shape changes and neighbor rearrangements. We quantify the space and time heterogeneity precisely enough to discriminate between models. We also explored the role of the boundaries conditions on the migration.
Together, our experiments and model disantangle the respective contributions of active velocity and of proliferation in monolayer migration. They highlight the importance of strain-polarity coupling and density in long-range information propagation, and show that both elastic and viscous effects can have comparable contributions in the process of collective cell migration. Finally, we discuss the link with in vivo cell migration.
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