Bulletin of the American Physical Society
APS March Meeting 2021
Volume 66, Number 1
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session C08: Physics and Chemistry of Polymer 3D Printing
3:00 PM–6:00 PM,
Monday, March 15, 2021
Sponsoring
Units:
DPOLY DSOFT GSNP DFD
Chair: Jinhye Bae,University of California, San Diego; Anthony Kotula, NIST
Abstract: C08.00004 : 3D Printed Absorber for Capturing Chemotherapy Drugs before they Spread through the Body*
3:36 PM–3:48 PM
Live
Presenter:
Hee Jeung Oh
(Chemical Engineering, Pennsylvania State University)
Authors:
Hee Jeung Oh
(Chemical Engineering, Pennsylvania State University)
Mariam Aboian
(Radiology and Biomedical Engineering, Yale School of Medicine)
Michael Yi
(Chemical and Biomolecular Engineering, University of California, Berkeley)
Jacqueline Maslyn
(Chemical and Biomolecular Engineering, University of California, Berkeley)
Whitney Loo
(Chemical and Biomolecular Engineering, University of California, Berkeley)
Xi Jiang
(Materials Sciences Division, Lawrence Berkeley National Laboratory)
Dilworth Parkinson
(Advanced Light Source Division, Lawrence Berkeley National Laboratory)
Mark Wilson
(Department of Radiology, University of California, San Francisco)
Terilyn Moore
(Department of Radiology, University of California, San Francisco)
Colin Yee
(Department of Radiology, University of California, San Francisco)
Gregory Robbins
(Carbon, Inc.)
Florian Barth
(Carbon, Inc.)
Joseph DeSimone
(Chemical Engineering, Stanford University)
Steven Hetts
(Department of Radiology, University of California, San Francisco)
Nitash Balsara
(Chemical and Biomolecular Engineering, University of California, Berkeley)
In the context of reducing the toxicity of chemotherapy, we have designed, built, and deployed porous adsorbers for capturing chemotherapy drugs from the blood stream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The porosity was obtained by 3D printing of lattice structures within a cylinder. The surface of porous cylinders was coated with an ion-containing nanostructured block polymer which is responsible for capturing doxorubicin, a widely used chemotherapy drug with significant toxic side effects. Using a swine model, we show that our initial design enables the capture of 69 % of the administered drug without any immediate adverse effects. This development represents a significant step forward in minimizing toxic side effects of chemotherapy.
*NIH
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