Bulletin of the American Physical Society
APS March Meeting 2021
Volume 66, Number 1
Monday–Friday, March 15–19, 2021; Virtual; Time Zone: Central Daylight Time, USA
Session A15: Physics in Medicine: Innovations in Modeling and Therapy
8:00 AM–10:12 AM,
Monday, March 15, 2021
Sponsoring
Unit:
GMED
Chair: Matija Milanic
Abstract: A15.00005 : Evaluation of probabilistic radiotherapy planning in prostate cancer*
8:48 AM–9:00 AM
Live
Presenter:
Peter Ferjancic
(University of Wisconsin - Madison)
Authors:
Peter Ferjancic
(University of Wisconsin - Madison)
Uulke A. v.d. Heide
(Radiation Oncology, Leiden UMC)
Robert Jeraj
(University of Wisconsin - Madison)
In this work, we evaluate the performance of a probabilistic treatment planning approach using voxel-based tumor likelihood maps and robust optimization (RO), where the objective function is calculated with different scenarios of uncertainty realizations, which more realistically represents treatment planning and delivery than safety margins. Using in-house developed Tomotherapy treatment planning software we calculated and evaluated treatment plans for eleven prostate cancer patients with MRI-derived tumor likelihood maps. Plans were created using classical approach and RO with different scenario selection and optimization functions. The RO approach was able to create comparable plans to existing classical planning, as well as create dose plans based on tumor likelihood maps and plans with heterogeneous dose prescription.
*Partially funded by the University of Wisconsin Carbone Cancer Center Support Grant P30 CA014520
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