Bulletin of the American Physical Society
APS March Meeting 2020
Volume 65, Number 1
Monday–Friday, March 2–6, 2020; Denver, Colorado
Session W23: Macromolecular Phase Separation in Biology III
8:00 AM–10:48 AM,
Friday, March 6, 2020
Room: 304
Sponsoring
Units:
DBIO DPOLY DSOFT GSNP
Chair: Patrick McCall, Max Planck Institute for the Physics of Complex Systems
Abstract: W23.00010 : The robust bioinformatic analysis of the protein sequences with phase behavior
Presenter:
Aleksandra Elzbieta Badaczewska-Dawid
(Iowa State University)
Authors:
Aleksandra Elzbieta Badaczewska-Dawid
(Iowa State University)
Davit Potoyan
(Iowa State University)
To reveal common motifs of protein sequences that promote PS, we have carried out large-scale statistical analysis of phase separating protein deposited in the LLPSDB database. For each motif, the most significant interactions have been identified (e.g. charge, hydropathy, polarity, pi-stacking). The bioinformatic analysis provides us with crucial knowledge about sequence conservation, secondary structure preferences, aggregation tendency, post-translational modification prediction, and binding affinity.
The long-term goal of our research is the creation of a publically accessible database that would be used by both experimentalists for designing controlled mutations and for computationally-oriented scientists for developing new modeling tools.
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2024 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700