Dose-rate effects in the radiation induced mutation of Drosophila*

We proposed a mathematical model to study the biological effects of radiation which we call WAM model. (1) An important feature of the model is that it can describe the dose-rate dependence of the effects of radiation. We succeeded in reproducing the existing data of dose/dose-rate dependence of mutation frequencies of 5 species including animals and plants. (2) We hope to develop the model to desceibe the whole process from mutation to cancer generation.
In 1926, Herman Muller conducted the famous expetiments of the radiation-induced mutation in Drosphila, which shows a linear increase with the the total dose. Later, Purdom and McSheehy irradiated Drosophila with much lower dose rate to find out if there is a dose-rate dependence in the mutation frequency.(3) Here, we reexamine their date with WAM model and found that the data is reproduced well with our model. We will discuss the possible dose-rate dependence of the radiation-induced mutation frequency in Drosophila.

References
(1) Y. Manabe, T. Wada, et al., J. Phys. Soc. Jpn. 84 (2015) 044002.
(2) T.Wada, et al., J. Nucl. Sci. Tech. 53 (2016) 1824-1830.
(3) C.E.Purdom and T.W.McSheehy, Int. J. Rad. Biol. 7 (1963) 265-275.