Bulletin of the American Physical Society
APS March Meeting 2020
Volume 65, Number 1
Monday–Friday, March 2–6, 2020; Denver, Colorado
Session J35: Physics of Medical Imaging, Measurement, and Tissue Characterization
2:30 PM–5:18 PM,
Tuesday, March 3, 2020
Sponsoring Unit: GMED
Chair: Wojciech Zbijewski, Johns Hopkins University
Abstract: J35.00001 : Imaging the brain across scales using light, magnetic fields, and models*
View Presentation Abstract
(Univ of Laval)
(Univ of Laval)
Animal models provide invaluable insight for studying the cellular origin of fMRI. In mice, state-of-the-art optical technologies have been developed to probe neuronal activity, blood flow and oxygenation while manipulating cell-type-specific neuronal activity.
A framework for imaging the brain of awake behaving mice across scales, from two-photon microscopy at the micrometer scale to macroscopic fMRI, will be demonstrated. High-resolution 3D images of cerebral vasculature measured in mice can be graphed into a connected network to model blood circulation and oxygen diffusion. In this model, the physics of magnetic resonance are leveraged to predict human brain imaging signals. Applications in neuroscience and fundamental cancer research will be discussed.
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