Bulletin of the American Physical Society
APS March Meeting 2020
Volume 65, Number 1
Monday–Friday, March 2–6, 2020; Denver, Colorado
Session B06: Theoretical, Computational, and Statistical Modeling in Medicine
11:15 AM–2:15 PM,
Monday, March 2, 2020
Sponsoring Unit: GMED
Chair: Robert Austin, Princeton University
Abstract: B06.00001 : A statistical ensemble approach to understanding adaptive immunity: using sequence data to quantify the extraordinary diversity, in both sequence and protective specifictiy, of the T- and B-cells cells that make up an individual human's immune system.*
1. Statistical inference of the generation probability of T-cell receptors from sequence repertoires, with A.Murugan, T.Mora, and A.Walczak, Proc. Natl. Acad. Sci. USA, 109 (2012) 16161-16166.
2. OLGA: fast computation of generation probability of B- and T-cell receptor amino-acid sequences and motifs, with Y.Elhanati, Z.Sethna, T.Mora, and A.M.Walczak, Bioinformatics, 35 (2019) 2974-2981.
*The work of C. Callan is supported by NSF grants PHY-1607612 and PHY-1734030.
The American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics.
1 Physics Ellipse, College Park, MD 20740-3844
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700