Bulletin of the American Physical Society
APS March Meeting 2020
Volume 65, Number 1
Monday–Friday, March 2–6, 2020; Denver, Colorado
Session A26: Mechanics of Cells and Tissues Across Scales I
8:00 AM–11:00 AM,
Monday, March 2, 2020
Sponsoring Units: DBIO GSNP DSOFT DPOLY
Chair: Kandice Tanner, National Institutes of Health - NIH
Abstract: A26.00009 : Classification of healthy and cancerous cells using optical rheology and machine learning*
Josef Alfons Kaes
We use the high throughput of the OS to perform machine learning based discrimination of individual cells with a breast cancer model. We performed around 30,000 single cell stretching experiments on epithelial cells (MCF-10A), carcinoma cells (MDA-MB 436) and fibroblasts (NIH 3T3), and extracted 33 morphological and rheological parameters to use them for classification with random forest and support vector machine algorithms. Our approach allows us to distinguish among the three cell types with an average sensitivity of 71%. These intial results do not only elevate the importance of the mechanics of cells during tumor progression, but also promise live cell sorting for scientific and medical applications.
*European Research Council (ERC-741350/HoldCancerBack), European Union and the European Social Fond in Saxony (ESF-100234741).
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