Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session V23: Low Temperature Instrumentation
2:30 PM–4:18 PM,
Thursday, March 7, 2019
BCEC
Room: 158
Sponsoring
Unit:
GIMS
Abstract: V23.00008 : Single cell temperature measurement with a thin-film thermocouple array
(Author Not Attending)
Presenter:
Fan Yang
(Key Laboratory for the Physics & Chemistry of Nanodevices, and Department of Electronics, Peking University)
Authors:
Fan Yang
(Key Laboratory for the Physics & Chemistry of Nanodevices, and Department of Electronics, Peking University)
Sheng-Yong Xu
(Key Laboratory for the Physics & Chemistry of Nanodevices, and Department of Electronics, Peking University)
In this work, we developed high-performance Pd/Cr micron thin-film thermocouple (TFTC) arrays and double-stabilized system with a stability of ±5 mK for single cell temperature measurement. We have obtained frequent temperature increments of 10-60 mK and a maximum up to 200-300 mK for cultured HepG2 cells1. Recently, we have reduced the stripe width of TFTC down to 170 nm,and fabricated 10×10 TFTC arrays on 100×100 µm2 Si3N4 suspended platforms. We aim to realize the real-time 2D mapping of local temperature distribution for a single live cell with our nano-sized TFTC arrays and double-stabilized measurement system. The measurement results may shed some light on further investigation in determining the absolute temperature distribution of individual cultured live cells, both outside and inside of the cells, in a more precise way.
1. F. Yang, et al., Scientific Reports, 7, 1721 (1-11) (2017).
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