Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session S65: Physics of Genome Organization II
11:15 AM–2:15 PM,
Thursday, March 7, 2019
BCEC
Room: 260
Sponsoring
Units:
DBIO DPOLY GSNP
Chair: Alexandre Morozov, Rutgers Univ
Abstract: S65.00009 : Interplay of Loop Extrusion, Compartmentalization and Global Chromosome Dynamics Across Conditions and the Cell Cycle*
1:15 PM–1:27 PM
Presenter:
Johannes Nuebler
(IMES, MIT)
Authors:
Johannes Nuebler
(IMES, MIT)
Geoffrey Fudenberg
(Gladstone Institutes, USCF)
Maxim Imakaev
(IMES, MIT)
Nezar Abdennur
(IMES, MIT)
Leonid Mirny
(IMES, MIT)
We explore to what extent comparatively simple polymer physics explains chromosome organization, and where its shortcomings indicate more specific, biological mechanisms. Specifically, we show that the interplay loop extrusion and compartmentalization is a crucial aspect of interphase organization: several mutants targeting the loop extrusion machinery also affect compartmentalization. (PNAS 115, E6697). Furthermore, we investigate the joint dynamics of loop extrusion, compartmentalization, and chromosome intermingling during entry into and exit from mitosis.
*NSF 150494, NIH GM114190, NIH DK107980
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