Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session R30: Physics of Bio-Inspired Materials
8:00 AM–10:48 AM,
Thursday, March 7, 2019
BCEC
Room: 162B
Sponsoring
Units:
GSOFT DBIO
Chair: Kyoo-Chul (Ken) Park, Northwestern University
Abstract: R30.00012 : Self-assembly of protein-made structures
10:36 AM–10:48 AM
Presenter:
Agnese Curatolo
(Harvard University)
Authors:
Agnese Curatolo
(Harvard University)
Carl Goodrich
(Harvard University)
Ofer Kimchi
(Harvard University)
Michael Phillip Brenner
(Harvard University)
Scott Boyken
(University of Washington)
Zibo Chen
(University of Washington)
Yang Hsia
(University of Washington)
David Baker
(University of Washington)
To achieve this goal, we need to understand and re-design the rules used by nature to encode specificity in protein interactions. Sophisticated techniques for designing proteins de novo have been developed recently in David Baker's lab. These proteins interact via designed hydrogen-bonding networks and can be used as building blocks to fabricate functional materials. The drawback is the enormous space of interactions that can be designed.
In order to explore this space and identify the interactions which lead to specific mechanical properties, we need to understand the link between the protein building blocks and the target structures to assemble. In this talk I will present a theoretical/computational model to predict the yield of some simple protein-made structures as a function of few controlling parameters, such as the binding energies and the concentration of the building blocks.
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