Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session P67: Physics of Neural Systems I
2:30 PM–5:30 PM,
Wednesday, March 6, 2019
BCEC Room: 050
Sponsoring Unit: DBIO
Chair: Joshua Shaevitz, Princeton University
Abstract: P67.00008 : Long-lasting desynchronization achieved by decoupling stimulation
4:18 PM–4:30 PM
Peter A. Tass
Abnormally strong synchronization of neuronal activity is a hallmark of several brain disorders. In Parkinson’s patients, deep brain stimulation is permanently delivered at high frequencies (> 100 Hz) to suppress symptoms. A qualitatively different, theory-based approach uses dedicated stimulus patterns to cause a desynchronization-induced decoupling of oscillatory neurons. Corresponding long-lasting desynchronizing effects were demonstrated in animal and clinical studies. However, parameters of desynchronizing stimuli, e.g. the stimulation frequency, have to be adapted to the dominant neuronal rhythm. This is an issue since different abnormal brain rhythms may coexist.
We here present a novel approach which causes long-term desynchronization by decoupling stimulation, primarily targeting the slow synaptic weight dynamics - Random Step (RS) stimulation. It ultimately leads to full-blown desynchronization by shifting neural networks from attractors with synchronized to attractors with desynchronized neuronal activity. Compared to desynchronizing stimulation techniques, the acute desynchronizing effect of RS stimulation is weaker, but the robust long-lasting effect does not require fine-tuning to the dominant neuronal rhythms. This may enable novel clinical applications.
The American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics.
1 Physics Ellipse, College Park, MD 20740-3844
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700