Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session P64: Systems Biology and Stochasticity in Biological Networks
2:30 PM–5:30 PM,
Wednesday, March 6, 2019
BCEC
Room: 259B
Sponsoring
Unit:
DBIO
Chair: Po-Yi Ho, Harvard University
Abstract: P64.00004 : Non-steady-state dynamics and growth optimization of scalable flux networks
3:06 PM–3:18 PM
Presenter:
Wei-Hsiang Lin
(Yale Univ)
Authors:
Wei-Hsiang Lin
(Yale Univ)
Edo Kussell
(Center of Genomic and Systems Biology, New York University)
Christine Jacobs-Wagner
(Yale Univ)
Scalable networks expand our analytic tools for studying non-steady-state growing systems, including the cell cycle and oscillating ecosystems. We demonstrate how scalable networks facilitates the analysis of objective functions in flux optimization, and use them for characterizing the essential motif of autocatalytic flux networks. Overall, our theory allows systematic construction of nonlinear networks and investigate their growth rate under optimization, regulation and perturbation.
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