Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session L70: Poster Session II (11:15am-2:15pm)
Wednesday, March 6, 2019
BCEC Room: Exhibit Hall
Abstract: L70.00339 : Mining recombination algorithms in modular biosynthetic gene clusters
In large database, correlations between different subunits of NRPS can be uncovered by statistic techniques. However, as subunits in the same gene cluster are correlated by sharing the same lineage history, the correlation induced by functional constraints usually get blurred.
A unique marine bacteria described in our previous research reveals important design principles of NRPS. In this bacteria, 20 NRPS pathways generate chemical diversity though extremely frequent recombination. Genetic exchange between NRPSs is so intensive that it largely erases the correlation by lineage history, leaving correlation by function clearly observable. In this system, we revealed previously undescribed constraints between different types of subunits of NRPS.
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