Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session H65: Controlling Cells with Electric Fields
2:30 PM–5:30 PM,
Tuesday, March 5, 2019
BCEC
Room: 260
Sponsoring
Unit:
DBIO
Chair: Wolfgang Losert, University of Maryland, College Park
Abstract: H65.00002 : Precisely regulate ERK signaling pathway with local electric fields*
3:06 PM–3:42 PM
Presenter:
Quan Qing
(Arizona State University)
Author:
Quan Qing
(Arizona State University)
In this presentation I will talk about our recent discovery of modulation of extracellular-signal-regulated kinase (ERK) pathway using alternative current (AC) electric fields (EFs). The amplitude, duration, and frequency of activation of the ERK pathway code diverse spectrum of information at cell, tissue and organism levels to instruct cells to migrate, proliferate, or differentiate. Synchronized control of ERK activation would provide a powerful approach to regulate cell behaviors. Here we show for the first time that AC EFs in a new frequency range can reproducibly activate ERK activities through patterned local microelectrodes with single-cell resolution. Both the amplitude and frequency of ERK activation can be precisely synchronized and modulated. We pinpointed a new mechanism of AC EF induced highly specific phosphorylation of epidermal growth factor (EGF) receptor (EGFR) to activate the EGFR-ERK pathway, which may serve as a powerful platform for control of cell behaviors with implications in wide range of biomedical applications.
*We acknowledge the support by the Air Force Office of Scientific Research under award number FA9550-16-1-0052, and the support by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under award number R21EB020822.
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