Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session B64: Biopolymers I (DNA, RNA, Biocompatible, Gels)
11:15 AM–2:03 PM,
Monday, March 4, 2019
BCEC
Room: 259B
Sponsoring
Unit:
DBIO
Abstract: B64.00008 : Spatially-defined active matter using DNA strands
12:39 PM–12:51 PM
Presenter:
Anis Senoussi
(Sorbonne Universite and CNRS, Laboratoire Jean Perrin, Paris, France)
Authors:
Anis Senoussi
(Sorbonne Universite and CNRS, Laboratoire Jean Perrin, Paris, France)
Jean-Christophe Galas
(Sorbonne Universite and CNRS, Laboratoire Jean Perrin, Paris, France)
André Estevez-Torres
(Sorbonne Universite and CNRS, Laboratoire Jean Perrin, Paris, France)
We designed a minimal system composed of protein filaments and modified molecular motors that can convert chemical energy into large-scale mechanical work upon the addition of a specific DNA strand. We expressed and purified each molecular components and rationally-assembled them to create a DNA-responsive material. This material undergoes macroscopic changes resulting in global or local contractions. This approach can be used to create original out-of-equilibrium systems that link a DNA-based chemical reaction network capable of generating a concentration landscape, as previously demonstrated [1], with a force-generating system.
[1] Zadorin et al., Nat. Chem. (2017)
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