Bulletin of the American Physical Society
APS March Meeting 2018
Volume 63, Number 1
Monday–Friday, March 5–9, 2018; Los Angeles, California
Session R48: Physics of Intracellular Membranes and Organelles
8:00 AM–11:00 AM,
Thursday, March 8, 2018
LACC
Room: 510
Sponsoring
Units:
GSNP DBIO
Chair: Bodo Wilts, University of Fribourg
Abstract ID: BAPS.2018.MAR.R48.2
Abstract: R48.00002 : Formation of Coatless Membrane Vesicles*
8:36 AM–8:48 AM
Presenter:
Susanne Liese
(Department of Mathematics, University of Oslo)
Authors:
Susanne Liese
(Department of Mathematics, University of Oslo)
Rossana Rojas
(Department of Mathematics, University of Oslo)
Eva Wenzel
(Institute for Cancer Research, Oslo University Hospital)
Camilla Raiborg
(Institute for Cancer Research, Oslo University Hospital)
Harald Stenmark
(Institute for Cancer Research, Oslo University Hospital)
Andreas Carlson
(Department of Mathematics, University of Oslo)
The formation of membrane vesicles is an important part of various processes in cell biology. Among others, cells use vesicle formation as an uptake mechanism for controlling their activity and to communicate with other cells through the cargo material that is encapsulated in the membrane vesicle. It all starts with a small initial deformation of the membrane, which subsequently grows and leads to the formation of a vesicle. This dynamic process is induced by membrane associated proteins, which generate forces within the membrane. Membrane compartments inside the cell, such as the endosome, form coatless vesicles but the force generating membrane proteins are not becoming a part of the vesicle. To understand this process, we develop an elastic membrane model to study the biophysical origin of coatless vesicle formation. Our results highlight how elastic membrane parameters and transmembrane proteins determine the shape of the deformed membrane and the equilibrium size distribution of vesicles.
*This work was supported by the Norwegian Research Council within the grant 263056.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2018.MAR.R48.2
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