Bulletin of the American Physical Society
APS March Meeting 2018
Volume 63, Number 1
Monday–Friday, March 5–9, 2018; Los Angeles, California
Session H42: Physical Approaches to Collective Cell MotilityInvited
|
Hide Abstracts |
Sponsoring Units: GSNP Chair: Herbert Levine, Rice University Room: LACC 502B |
Tuesday, March 6, 2018 2:30PM - 3:06PM |
H42.00001: Confinement and substrate topography control 3D cell migration Invited Speaker: Igor Aronson Cell movement in vivo is often characterized by strong confinement and heterogeneous, three-dimensional environments. Such external constraints on cell motility are known to play important roles in many vital processes, e.g. during development, differentiation, and the immune response, as well as in threatening pathologies like cancer metastasis. A three-dimensional computational modeling framework that describes a lamellipodium-based motion of cells in arbitrarily shaped and topographically structured external surroundings is developed. It includes the in vitro model systems that are currently studied experimentally: like well-designed modulations of surface topography, cells in vertical confinement, in microchannels and on fibers. While other modes of motion beyond lamellipodia are often triggered by the confinement, our model can serve as a benchmark to explore this specific motility mode and its interaction with the environment in depth. Both topographical features and confinement modulate the cell's speed, shape, actin organization and can induce changes in direction along preferred axes defined by the constraints.It is also found that substrate curvature (with radii of the order of the cell size and below) affect the speed of migration and can even impede motion. |
Tuesday, March 6, 2018 3:06PM - 3:42PM |
H42.00002: Cell-to-cell variability, tissue rheology, and collective measurements Invited Speaker: Brian Camley When cells cooperate to sense a signal, such as a cluster of cells performing collective chemotaxis, they must deal with cell-to-cell variability: even genetically identical cells can have differing responses to chemical signals. We show theoretically and computationally that variability in signaling can limit collective chemotaxis. This occurs because when a strongly responding cell is at one end of a cell cluster, cluster motion is biased toward that cell. These errors can be mitigated if clusters average measurements over times long enough for cells to rearrange - fluid clusters are better able to sense gradients: We develop a bound controlling cluster accuracy as a function of cell-to-cell variation and cluster rheology. We also discuss methods to more accurately measure cell-to-cell variability in both motility and signaling properties, as well as applying our theory to experimental measurements of cluster rearrangement. |
Tuesday, March 6, 2018 3:42PM - 4:18PM |
H42.00003: Collective cell migration in electric fields Invited Speaker: Alex Mogilner Fish keratocyte cells migrate rapidly and persistently. Electric field is directionl cue |
Tuesday, March 6, 2018 4:18PM - 4:54PM |
H42.00004: Multiple scale model for cell migration in monolayers: Elastic mismatch between cells enhances motility Invited Speaker: Martin Grant We propose multiscale phase-field and sharp-interface models for a monolayer of motile cells that comprise normal and cancer cells. The two types of cells have identical properties except for their elasticity; cancer cells are softer and normal cells are stiffer. Simulation results demonstrate that elasticity mismatch alone is sufficient to increase the motility of the cancer cell significantly. Further, the trajectory of the cancer cell is decorated by several speed “bursts” where the cancer cell quickly relaxes from a largely deformed shape and consequently increases its translational motion. The increased motility and the amplitude and frequency of the bursts are in qualitative agreement with recent experiments. The computational efficiency of the sharp-interface model allows us to investigate the nature of the cell distribution functions. |
Tuesday, March 6, 2018 4:54PM - 5:30PM |
H42.00005: Abstract Withdrawn Invited Speaker: |
Follow Us |
Engage
Become an APS Member |
My APS
Renew Membership |
Information for |
About APSThe American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics. |
© 2024 American Physical Society
| All rights reserved | Terms of Use
| Contact Us
Headquarters
1 Physics Ellipse, College Park, MD 20740-3844
(301) 209-3200
Editorial Office
100 Motor Pkwy, Suite 110, Hauppauge, NY 11788
(631) 591-4000
Office of Public Affairs
529 14th St NW, Suite 1050, Washington, D.C. 20045-2001
(202) 662-8700