The Assembly of Cyclopeptide-Polymer Conjugates and Block Polymer

The co-assembly of cyclopeptide-polymer conjugates and block polymer affords a simple route to generate hierarchical structures with molecular level control over the assemblies. By coupling synthetic homopolymer to a preformed cyclic (D-alt-L)-R- octapeptide, a family of coil-ring-coil bioconjugates was synthesized. The controlled self-assembly of the conjugate leads to uniform nanoparticle structures, 2.5-3nm in height and 25- 30nm in diameter. The assembly of blends of cyclopeptide-polymer conjugates and block polymer has been further investigated. The co-assembly of cyclopeptide-polymer conjugates and diblock copolymer provide a base to generate nanoporous materials and improve our understanding in the self-assembly of mutli- component hybrid systems.