Bulletin of the American Physical Society
75th Annual Gaseous Electronics Conference
Volume 67, Number 9
Monday–Friday, October 3–7, 2022;
Sendai International Center, Sendai, Japan
The session times in this program are intended for Japan Standard Time zone in Tokyo, Japan (GMT+9)
Session EF2: Plasma Medical & Agricultural Application II
10:00 AM–11:45 AM,
Friday, October 7, 2022
Sendai International Center
Room: Hagi
Chair: Nevena Puac, Institute of Physics Belgrade Serbia
Abstract: EF2.00003 : Influence of COST-Jet produced Short-lived RONS on Cellular Responses*
10:45 AM–11:00 AM
Presenter:
Maria J Herrera Quesada
(North Carolina State University)
Authors:
Maria J Herrera Quesada
(North Carolina State University)
Cameron Wagoner
(North Carolina State University)
Katharina Stapelmann
(North Carolina State University)
This research used the COST-jet with three different gas admixtures tailored to have high effluent concentrations of ·NO (He + 0.2% O2 + 0.8% N2), ·OH (He + 2500 ppm H2O), or O (He + 0.6% O2). The relative aqueous concentrations of short-lived RONS were measured by Electron Paramagnetic Resonance (EPR) spectroscopy in solutions with organic components to investigate their interaction with RONS. These experiments resulted in parameter selection (gas admixture and treatment time) for in vitro treatments that reflect high aqueous concentrations of 1) ·NO, 2) O, and 3) ·OH. In vitro experiments consisted of plasma treatment of pancreatic tumor cell cultures (KPC 4662) with the selected parameters from the EPR studies to compare the cells’ viability and released immunogenic cell death (ICD) markers. These studies will contribute to future plasma cancer treatment strategies by characterizing the effectiveness of different RONS abundance to treat cancer cells.
*This project was partially funded through the UNC Lineberger Developmental Funding Program.
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