Bulletin of the American Physical Society
71st Annual Meeting of the APS Division of Fluid Dynamics
Volume 63, Number 13
Sunday–Tuesday, November 18–20, 2018; Atlanta, Georgia
Session M18: Biological fluid dynamics: Hemodynamics
8:00 AM–10:10 AM,
Tuesday, November 20, 2018
Georgia World Congress Center Room: B305
Chair: Amirhossein Arzani, Northern Arizona University
Abstract ID: BAPS.2018.DFD.M18.9
Abstract: M18.00009 : Uncertainty quantification for patient-specific cardiovascular simulations in high-performance computing*
9:44 AM–9:57 AM
Daniele E. Schiavazzi
(University of Notre Dame)
Alison L Marsden
Cardiovascular blood flow simulations solve the incompressible Navier-Stokes equations in patient-specific geometries constructed from image data with physiologic boundary conditions. To assess variabilities of simulation predictions under uncertainties in clinical measurements, we perform uncertainty quantification. In our computational model, we account for fluid-structure interaction, coupling blood flow with deformable vessel walls via an Arbitrary-Lagrangian-Eulerian framework, and open-loop lumped parameter boundary conditions to model the peripheral circulation. We consider multiple sources of input uncertainty, including uncertainties in inflow waveform, material properties, and resistance boundary conditions. We introduce several strategies to reduce computational cost for forward uncertainty propagation using Kalhunen-Loeve expansion and a sub-modeling approach. We report statistics on quantities of interest including flow rate, pressure at the distal vessel branches, time-averaged wall shear stress, and wall displacement. Comparisons of several forward uncertainty propagation methodologies will be discussed including Monte Carlo and a recently proposed multiresolution framework.
*Support from National Institute of Health (R01 EB018302) is greatly appreciated.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2018.DFD.M18.9
The American Physical Society (APS) is a non-profit membership organization working to advance the knowledge of physics.
1 Physics Ellipse, College Park, MD 20740-3844
Editorial Office 1 Research Road, Ridge, NY 11961-2701 (631) 591-4000
Office of Public Affairs 529 14th St NW, Suite 1050, Washington, D.C. 20045-2001 (202) 662-8700