Study type B aortic dissection using a deconvolution-based nonlinear filter*

Progressive false lumen aneurysmal degeneration in type B aortic dissection (TBAD) is a complex process with a multi-factorial etiology. Patient-specific computational fluid dynamics simulations provide spatial and temporal hemodynamics factors and registration methods quantify the morphological changes of the false lumen (FL). By considering both simultaneously, correlations can be established to potentially help understanding the intertwining between hemodynamics and false lumen progression. A deconvolution-based nonlinear filter is applied to Navier-Stokes equations with a specific calibration method for the boundary conditions. Correlations between hemodynamics and the deformation of the FL are investigated. Moreover, backflow stabilization effect of the filter and sensitivity of the filter parameter are studied. The model is able to capture the flow properties accurately with a large reduction in computational time. The time averaged wall shear stress is found to correlate positively with FL dilation (𝑟² = 0.44). A mild negative correlation is found between oscillatory shear index and deformation (𝑟² = 0.29). High relative residence time is suspected to be correlated with thrombose absorption.