Bulletin of the American Physical Society
APS April Meeting 2019
Volume 64, Number 3
Saturday–Tuesday, April 13–16, 2019; Denver, Colorado
Session H02: New Detectors for Medical Imaging: Translating Discoveries from Nuclear and Particle Physics to MedicineInvited Undergraduate
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Sponsoring Units: GMED Chair: Peter Krizan, Ljubljana University and J. Stefan Institute Room: Sheraton Plaza D |
Sunday, April 14, 2019 10:45AM - 11:09AM |
H02.00001: Nanocrystal-based scintillators for TOF-PET with ultimate time resolution Invited Speaker: Paul Lecoq The 10ps TOFPET challenge [1] requires a parallel effort on all the components of the detector chain (crystal, photodetector, readout electronics). Even with the best presently available SiPM photodetectors, the most popular scintillators for PET (L(Y)SO, L(G)SO, LaBr3) are limited in their timing performance at low energy and a mechanism to produce a few hundred prompt photons on top of the scintillation signal is necessary in order to reach 10ps coincidence time resolution (CTR) at 511keV. This contribution describes our work for developing a metamaterial-based scintillator block having these characteristics. A quantitative justification will be given, based on our measurements, for a combination of L(Y)SO, in form of block, plates or fibers with:
Simulation results for different, but not yet optimized, geometrical configurations of the metamaterial structure show that an energy leakage from LYSO to the fast component of the metastructure of ≥ 100keV can be obtained for about 20% of the 511keV -rays fully converted in the metastructure, inducing the production of »250 prompt photons on CdSe nanoplatelets on top of the LYSO scintillation signal. Evidence of this prompt emission has been obtained in our lab on a simple heterostructure made of 200micron thick LYSO plates covered by CdSe nanoplatelets layers deposited by drop casting. Results on more metastructures configurations will be given at the time of the conference. [1] P. Lecoq, “Pushing the limits in Time-Of-Flight PET imaging”, IEEE Trans. Rad. Pl. Med. Sc., NOV. 2017. Volume: 1 Issue: 6, pp 473-485 |
Sunday, April 14, 2019 11:09AM - 11:33AM |
H02.00002: Compact and Handheld Radioisotope Imaging Systems for Bio-medicine Invited Speaker: Andrew Weisenberger Thomas Jefferson National Accelerator Facility is a U.S. Department of Energy federally funded research and development center whose mission is to study quark gluon physics. The laboratory capitalizes on its unique technologies and expertise to explore ways of applying nuclear physics principles and technologies to societal needs. The Radiation Detector and Imaging Group, in collaboration with universities, industry and other government laboratories, has for several years been applying advances in nuclear physics detector technology to several applications, particularly in the development of compact and handheld nuclear imaging systems. I will provide a brief overview of Jefferson Lab and provide examples of how the group has leveraged nuclear physics to bring advances to nuclear medicine, medical research and plant biology. The group continues to develop medical devices based on both single photon emission computed tomography (SPECT) and positron emission tomography (PET), making use of technology originally developed for basic nuclear physics research. |
Sunday, April 14, 2019 11:33AM - 11:57AM |
H02.00003: Ultrafast detection in positron emission tomography using Cherenkov light Invited Speaker: Peter Krizan The talk will discuss the development of a novel PET scanner concept which is cost-effective, could have a higher patient throughput, and would also allow for the construction of a full-body PET apparatus. The resulting detection system would provide the basis for increased sensitivity in cancer detection, providing a more robust diagnosis for an early therapy selection in an individual patient. The scanner will be based on the detection of the annihilation gammas by using Cherenkov light, thus translating basic particle physics experiments to clinical PET. We will report on a series of experimental and simulation studies that have shown that with this detection concept TOF resolutions below 100 ps are possible, that silicon photomultipliers present a very promising device for Cherenkov light detection in TOF PET, and that such an apparatus offers a very interesting cheaper alternative to scintillating crystal based scanners. |
Sunday, April 14, 2019 11:57AM - 12:21PM |
H02.00004: Frontiers in X-ray Imaging - Applications of Photon Counting Spectral Detectors (Medipix) Invited Speaker: Mini Das Photon counting spectral detectors which can allow separation of photons by their energy and/or time of arrival may have significant applications in medical and biological imaging. Some obvious applications can be "color x-ray imaging" and material decomposition techniques to obtain quantitative maps of chemical or biological compositions. Our group has pioneered the applications of these detectors in more challenging imaging scenarios. This includes extracting phase changes of x-rays as they propagate through objects. These phase retrieval methods aided by spectral detectors have the potential to combine multiple contrast features in a single, low dose acquisition. I will describe these general concepts as well as our ongoing work with PCDs, in particular those developed by the CERN based Medipix collaboration. |
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