Session D21: Focus Session: Novel Instrumentation & Measurements for Biomedical Research
2:30 PM–5:30 PM, Monday, March 21, 2011
Room: D161
Sponsoring Unit:
GIMS
Chair: Larry Nagahara, National Institutes of Health
Abstract ID: BAPS.2011.MAR.D21.3
Abstract: D21.00003 : Carbogen Enhanced Femto Oximetry Breast Cancer Diagnosis Method with High Specificity
3:18 PM–3:30 PM
Preview Abstract
MathJax On | Off 
Abstract 
Authors:
Bogdan C. Maglich
(California Science and Engineering Corp.)
J.K. Shultis
(Kansas State University)
C.J. Solomon
(Kansas State University)
As large malignant tumors are oxygen deficient (hypoxic), cancer could be diagnosed \textit{in vivo} and online, by non-invasive measurement of oxygen difference between tumor and adjacent tissue. Computer simulations of noninvasive diagnosis by Femto Oximetry (FO) of hypoxia in 1 cm tumor in 10 cm breast shows that background $\gamma $'s from non hypoxic tissue will mask hypoxia. To amplify the hypoxic-to-normal O difference, air breathing will be replaced with carbogen (O$_{2}$ 95{\%}, CO$_{2}$ 5{\%}) using vasco-constrictive property whereby carbogen breathing increases O in normal tissue, while not in malignant hypoxic tumors. 90{\%} hypoxia will be detectable by FO with specificity 99{\%}. Our method will be tested on R3230 tumors in Fischer rats at UCI.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2011.MAR.D21.3