Bulletin of the American Physical Society
APS March Meeting 2010
Volume 55, Number 2
Monday–Friday, March 15–19, 2010; Portland, Oregon
Session D10: Focus Session: Single Molecule Biophysics and Chemical Physics III
2:30 PM–5:30 PM,
Monday, March 15, 2010
Sponsoring Units: DCP DBP DPOLY
Chair: Rob Phillips, California Institute of Technology
Abstract ID: BAPS.2010.MAR.D10.3
Abstract: D10.00003 : Single Molecule Manipulation and Self-Assembly of Amyloid $\beta $/A4 Precursor Protein on Ag(111)*
3:18 PM–3:30 PM
Preview Abstract Abstract
We perform a single molecule level study of the RERMS sequence of amyloid $\beta $/A4 precursor protein fragment on a clean Ag(111) surface using a low-temperature scanning-tunneling-microscope (STM) system at 5K. The mechanical stability of individual protein fragments are checked by laterally manipulating them with the STM tip. Moreover, we are able to form a well ordered two-dimensional layer of the protein fragment by increasing the deposition time. A unit cell has been assigned and a model for the molecular arrangement inside the structure is proposed. This work opens possibilities of using well ordered protein structures on inorganic surfaces for future bimolecular electronic and nano-bio applications.
*The project is supported by NSF-EMT: CCF-0622158 grant.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2010.MAR.D10.3
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