Session V7: Oscillations and Segmentation: Dynamical Genetic Regulation in Time and Space
11:15 AM–2:15 PM, Thursday, March 13, 2008
Morial Convention Center Room: RO5
Sponsoring Units:
DBP GSNP
Chair: Mogens Jensen, Niels Bohr Institute
Abstract ID: BAPS.2008.MAR.V7.2
Abstract: V7.00002 : Modelling Ultradian Oscillations and Segmentation
11:51 AM–12:27 PM
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Abstract 
Author:
Mogens Jensen
(Niels Bohr Institute)
We model ultradian oscillations in four different eucaryotic systems: Hes1, p53-mdm2, NF-kB and Wnt-Notch. In each of the systems we identify the feed-back loops for the genetic regulations. Oscillations are possible when time delays are present, either by directly introducing a delay, by many steps in the loops or by saturated degradation. The oscillations are important for apoptosis and control of inflammation. The Wnt-Notch system is essential in embryo segmentation and we introduce a model in which the Wnt oscillates by itself but drives the Notch cycle out of phase with the Wnt cycle, in good agreement with experimental observations.
To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2008.MAR.V7.2