Bulletin of the American Physical Society
APS March Meeting 2020
Volume 65, Number 1
Monday–Friday, March 2–6, 2020; Denver, Colorado
Session S23: Macromolecular Phase Separation in Biology I
11:15 AM–2:15 PM,
Thursday, March 5, 2020
Sponsoring Units: DBIO DSOFT GSNP DPOLY
Chair: Daphne Klotsa, University of North Carolina at Chapel Hill
Abstract: S23.00009 : Motif Sequences and Intracellular Phase Separation*
We find that motif sequences strongly influence the physical properties of model IDPs. Intuitively, each sequence has its own preference for inter- versus intra-protein bonds, which favor a condensed versus a dilute phase, respectively. As a result, the concentration of IDPs required for phase separation depends strongly on the motif sequence. Our work demonstrates the emergence of spatial order from conformational disorder, a process which may play a key role in intracellular organization.
*This work was supported in part by the National Science Foundation, through the Center for the Physics of Biological Function (PHY-1734030).
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