Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session R30: Physics of Bio-Inspired Materials
8:00 AM–10:48 AM,
Thursday, March 7, 2019
BCEC
Room: 162B
Sponsoring
Units:
GSOFT DBIO
Chair: Kyoo-Chul (Ken) Park, Northwestern University
Abstract: R30.00007 : Siderophore Inspired Molecules to Mediate Collagen Thin Film Adhesion
9:36 AM–9:48 AM
Presenter:
Roberto Andresen Eguiluz
(University of California, Santa Barbara)
Authors:
Roberto Andresen Eguiluz
(University of California, Santa Barbara)
George Degen
(University of California, Santa Barbara)
Eric Valois
(University of California, Santa Barbara)
Garrett Lindsey
(University of California, Santa Barbara)
Kai Kristiansen
(University of California, Santa Barbara)
Our SFA measurements indicate that Col-1 films remain strongly bound to the underlying mica substrate, even after repeated loading-unloading cycles. For only Col-1 films, we observed very weak adhesion forces, Fad < 5 mN/m. Adsorption of TLC-adhesive molecules to the Col-1 films significantly increased the force of adhesion, Fad, to > 50 mN/m. This adhesion remained constant over several hours.
These findings suggest that siderophore inspired molecules might be an improved alternative to existing bio-adhesives, as they have been proven to strongly bridge mineral surfaces5 (mimicking prosthesis metal surfaces) and now interacting with the main ECM component of mammal tissues, Col-1.
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