Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session K65: Phase Separation in Biological Systems
8:00 AM–10:48 AM,
Wednesday, March 6, 2019
BCEC Room: 260
Sponsoring Units: DBIO DPOLY GSNP GSOFT
Chair: Jean-Charles Walter, Université de Montpellier
Abstract: K65.00010 : Motif Sequences and the Statistical Physics of Intracellular Phase Separation*
9:48 AM–10:00 AM
(Ben Gurion University)
We find that motif sequences strongly influence the statistical properties of model IDPs. Intuitively, each sequence has its own set of spatial conformations which determine the relative entropy of inter- and intra-protein bonds. As a result, the concentration of IDPs required for phase separation depends strongly on the motif sequence. Our work demonstrates the emergence of spatial order from conformational disorder, a process which may play a key role in intracellular organization.
*This work was supported in part by the National Science Foundation, through the Center for the Physics of Biological Function (PHY-1734030).
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