Bulletin of the American Physical Society
APS March Meeting 2019
Volume 64, Number 2
Monday–Friday, March 4–8, 2019; Boston, Massachusetts
Session B58: Self-Assembly II
11:15 AM–2:15 PM,
Monday, March 4, 2019
BCEC
Room: 257A
Sponsoring
Unit:
GSOFT
Chair: Katherine Klymko, University of California, Berkeley
Abstract: B58.00004 : Self-Assembly of DNA origami capsids*
11:51 AM–12:03 PM
Presenter:
Stefan Paquay
(Brandeis University)
Authors:
Stefan Paquay
(Brandeis University)
Christian Sigl
(Physics, Technische Universität München)
Hendrik Dietz
(Physics, Technische Universität München)
Seth Fraden
(Brandeis University)
Michael F Hagan
(Brandeis University)
With the right design these triangles self-assemble into icosahedra similarly to virus coat proteins but on larger length- and timescales, with potential applications in functional materials.
To guide the design of these building blocks we perform molecular dynamics and kinetic Monte Carlo simulations of coarse-grained, rigid triangles with reactive patches. Specifically, we aim to identify regimes at which the triangles optimally self-assemble into icosahedra of 20 and 60 subunits. Finally, we qualitatively compare the predicted self-assembly kinetics and structures to experiments.
*This project is funded by the Brandeis MRSEC, NIH and the William Keck Foundation
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