Bulletin of the American Physical Society
70th Annual Gaseous Electronics Conference
Volume 62, Number 10
Monday–Friday, November 6–10, 2017; Pittsburgh, Pennsylvania
Session DT3: Bio-Medical Plasma Chemistry |
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Chair: Danil Dobrynin, Drexel University Room: Oakmont Junior Ballroom |
Tuesday, November 7, 2017 8:00AM - 8:30AM |
DT3.00001: Numerical Investigation of Interactions between Reactive Oxygen Species and Biological Membrane in Atmospheric Nonequilibrium Plasma with Molecular Dynamics Invited Speaker: Satoshi Uchida Recently, direct contact processes of plasma species with various substances such as liquids and biomaterials have been established using stable nonequilibrium plasma under atmospheric pressure. The advanced plasma technology has been applied to industrial treatments. In particular, plasma medicine is one of the most attractive applications. However, various interactions among multiphase interfaces are extremely complicated. Theoretical modeling and numerical simulation are essential for understanding of the above mechanism. For multiphase behaviors among plasma, gas, liquid and biological objects, the numerical simulations using molecular dynamics are suitable because of the simplicity on physical mechanics. In the present work, fundamental modeling of multiphase including plasma, gas, liquid and biological objects under atmospheric pressure is introduced, and typical procedures of molecular dynamics are briefly described. Some analytical examples of plasma - biological interface are reviewed in the latest topical applications. The chemical reactions between reactive oxygen species and biomolecule are described with respect to the temporal energy balance. The transport characteristics of reactive oxygen species in biological membrane are also discussed. [Preview Abstract] |
Tuesday, November 7, 2017 8:30AM - 8:45AM |
DT3.00002: Effects of gas-phase reactive species on generation of hydrogen peroxide and nitrite ion in plasma-activated medium Keigo Takeda, Naoyuki Kurake, Kenji Ishikawa, Hiromasa Tanaka, Makoto Sekine, Masaru Hori Plasma-activated medium (PAM) which is cell-culture medium irradiated by atmospheric pressure plasma jet (APPJ) has strong antitumor effects on the various kinds of cells. The irradiation of APPJ to the medium generates reactive oxygen and nitrogen species (RONS) in the aqueous-phase. The contributions of RONS in the PAM have been investigated to clarify the mechanism of selective killing of cancer. Hydrogen peroxide is well-known as one of reactive oxygen species to affect the cell response. Moreover, the synergic reactions of hydrogen peroxide and nitrite ion achieves the antitumor effect [1]. In order to investigate the reactions leading to the productions of hydrogen peroxide and nitrite ions in the medium, the gas-phase atomic and molecular radicals and radiations emitted from an AC excited Ar APPJ were measured by VUV absorption, laser induced fluorescence, optical emission spectroscopy. Moreover, the generated radicals in the aqueous-phase were measured by ESR techniques with spin-trapping. On the basis of the measurement results of reactive species, we will discuss the production pathways of hydrogen peroxide and nitrite ion in the gas-phase, aqueous-phase, and gas-liquid interface. [1] N. Kurake, et al., Arch. Biochem. Biophys., 605 (2016) 102. [Preview Abstract] |
Tuesday, November 7, 2017 8:45AM - 9:00AM |
DT3.00003: Characterization of Reactive Species Generation in Liquid Phase by Air Plasma Effluent Exposure Keisuke Takashima, Yutaka Kimura, Keisuke Shimada, Kenji Nihei, Toshiro Kaneko Generation of reactive oxygen and nitrogen species in the liquid phase, during exposure to air atmospheric pressure plasma effluent gas, is experimentally studied through reactive species measurements in gas and liquid phases. Admixture of the plasma effluent gas with the nitric oxides (NO and NO$_{\mathrm{2}})$ resulted in the significant production of N$_{\mathrm{2}}$O$_{\mathrm{5}}$ and HNO$_{\mathrm{3}}$ and consumption of ozone and NO or NO$_{\mathrm{2}}$ measured with FT-IR in gas phase. The effects of the admixture on the reactive species in the liquid phase are also analyzed with absorption spectroscopy for nitric acids and resulted in the significant increase of the nitrite concentration. The measured short-lived species in liquid phase with chemical probes suggest the importance of the liquid phase chemical reactions near the gas-liquid interface resulted from the dissolution of the plasma effluent species into the liquid phase. The experimental analysis on the reaction pathways will be discussed along the measured reactive species in gas and liquid phases. [Preview Abstract] |
Tuesday, November 7, 2017 9:00AM - 9:15AM |
DT3.00004: Cold plasma needle-activated ROS in liquid for cancer cell inactivation Chunqi Jiang, Esin B. Sozer, Shutong Song, Nicola Lai, Siqi Guo, P. Thomas Vernier Reactive oxygen and nitrogen species generated by atmospheric pressure, non-equilibrium plasmas in contact with liquid have been considered highly important agents in plasma medicine applications including bacterial disinfection, wound healing and cancer treatment. We report here measurements of ROS including hydroxyl radical and hydrogen peroxide in liquid exposed to nanosecond pulsed helium plasma jets in ambient air. The plasma was generated by a single needle powered by repetitive nanosecond multi-kilovolt pulses. OH radicals were measured in water as well as in biological media. Cancer cell lines including pancreatic and histiocytic lymphoma U-937 cells in suspension were inactivated after exposure to the plasma needle for less than one minute. Dependence of cell inactivation on the OH production in liquid is discussed. [Preview Abstract] |
Tuesday, November 7, 2017 9:15AM - 9:30AM |
DT3.00005: Functional recovery of hypoxic ischemic encephalopathy (HIE) by plasma inhalation to living body lungs Takamichi Hirata, Hiroki Watanabe, Sayaka Matsuda, Chihiro Kobayashi, Akira Mori, Yoshiki Kudo, Mitsutoshi Iwashita We performed to clarify the mechanism by which the irradiation / inhalation using atmospheric-pressure plasma promotes disease treatments such as burn wound1), lungs and heart disease2), and recovery of hypoxic ischemic encephalopathy (HIE). Especially, from the viewpoint of brain disease treatment, we are now accomplishing the experiments concerning plasma inhalation (method of inhaling plasma flow from living body lungs) to reproduce brain cells that became dysfunction by HIE. From the result of the plasma inhalation experiments using small animals (rat), the effect of controlling brain disease was found by inhaling the gas in a mixture of the plasma flow and N$_{\mathrm{2}}$O into the rat HIE model. This study was supported by a Grant-in-Aid for Scientific Research on Innovative Areas (No. 24108010) from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT). References: 1) T. Hirata \textit{et al.}, Jpn. J. Appl. Phys. 53, 010302 (2014). 2) C. Tsutsui \textit{et al.}, Jpn. J. Appl. Phys. 53, 060309 (2014). [Preview Abstract] |
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