Bulletin of the American Physical Society
Mid-Atlantic Section 2022 Meeting
Volume 67, Number 20
Friday–Sunday, December 2–4, 2022; University Park, PA, Pennsylvania State University
Session B02: Polymer Physics |
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Chair: Nathan Keim, Pennsylvania State University Room: Pennsylvania State University Thomas 113 |
Friday, December 2, 2022 5:00PM - 5:12PM |
B02.00001: The Irregular Motion of a Liquid Contact Line is a Memory Ashbell Abraham The contact line at the edge of a water drop on a horizontal surface has an irregular shape that does not relax to equilibrium, revealing the disorder of the solid substrate beneath. We show that a disordered contact line can store multiple nested memories of the magnitude of its past motion. To encode a memory, we ‘train’ the contact line to a steady state through slow, cyclic injections and withdrawals at a constant volume of liquid. Afterwards, further training only drives it through a hysteresis loop that returns the contact line to its steady state. Changing the volume amplitude results in a different shape but applying one cycle at the training amplitude returns the contact line to its steady state. If the amplitude ever exceeds the training amplitude, the memory is erased, and the steady state is lost. This behavior is reminiscent of return-point memory, a phenomenon best known in ferromagnets. Return-point memory, and the process of reaching a steady state, can give insight about the history dependence and reversibility of contact line motion, offer a new framework for manipulating its shape, and lets us compare this system to others that do not relax to equilibrium. |
Friday, December 2, 2022 5:12PM - 5:47PM |
B02.00002: Memories in Disordered Soft Matter Invited Speaker: Nathan C Keim While we are all familiar with information preserved on hard disks, DVDs, or paper, a vast array of the materials around us can store and recall memories—sometimes in surprising ways. From my lab's research, I will show a few ways that soft solids and suspensions of particles can form detailed memories when they are deformed. Examining a system's capacity to remember multiple things at once, and even to perform simple computations with them, reveals surprising connections among disparate forms of living and nonliving matter—and suggests possibilities for making materials more programmable and adaptive. |
Friday, December 2, 2022 5:47PM - 5:59PM |
B02.00003: Liquid Core Nanocapsule Formation Using Flash Nanoprecipitation Sophia N Taylor, Yuri Chung, Samuel Becker, Eleni P Hughes, Xinran Zhang, Edward R Van Keuren Nanocapsules are nanoparticles with a liquid core and solid shell. These materials have shown promise in applications such as in pharmaceuticals and as food additives. We have developed a series of nanocapsules using a method known as flash nanoprecipitation, in which a solution is rapidly mixed with a miscible non-solvent. We synthesized nanocapsules consisting of a polystyrene shell with a liquid core of n-hexadecane. The nanocapsules were characterized using dynamic light scattering, atomic force microscopy, scanning electron microscopy, and transmission electron microscopy. The particles showed changes in volume over time as our solvent evaporated, but their final volume was a linear function of the initial concentration of the polymer solution. This is similar to the behavior of single component nanoparticles synthesized with flash nanoprecipitation, and is explained using a droplet model. |
Friday, December 2, 2022 5:59PM - 6:11PM |
B02.00004: A novel polymer nanoparticle treatment for acute kidney injury Eleni P Hughes, Edward R Van Keuren, Harper Cartwright, Peter Kang, Jake Reder Acute kidney injury (AKI) is a common and often life-threatening surgery complication caused by an overproduction of reactive oxygen species (ROS) in the body. APP-103™ is a novel polymer-based therapeutic designed to treat and prevent AKI with an active ingredient, PVAX, that quenches ROS at the site of injury and releases an anti-inflammatory drug, vanillyl alcohol, as a product of this reaction. APP-103™ is formed by the emulsification-solvent evaporation method of nanoparticle formation. During this process, PVAX is dissolved into an organic solvent, dichloromethane (DCM), then added to a solution of polyvinyl alcohol (PVA) in water while undergoing high shear vortexing. As an emulsion forms, droplets of PVAX and DCM form and are stabilized by the PVA in the water phase. After the removal of excess DCM, centrifuge rinsing, and lypophilization, a powder of APP-103™ nanoparticles remains. Techniques including scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential measurements, and a hydrogen peroxide assay are used to characterize APP-103™. Ongoing work is aimed towards understanding the release kinetics of APP-103™ in contact with ROS and optimizing particle formulation for clinical use in humans. |
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