Bulletin of the American Physical Society
APS March Meeting 2024
Monday–Friday, March 4–8, 2024; Minneapolis & Virtual
Session Q36: Physics of the Immune System I: From Repertoire to Function
3:00 PM–6:00 PM,
Wednesday, March 6, 2024
Room: 103B
Sponsoring
Unit:
DBIO
Chair: Elizabeth Jerison, University of Chicago
Abstract: Q36.00010 : Computational detection of antigen-specific B-cell receptors
5:12 PM–5:24 PM
Presenter:
Maria Francesca Abbate
(École normal supérieure Paris-Saclay)
Authors:
Maria Francesca Abbate
(École normal supérieure Paris-Saclay)
Aleksandra M Walczak
(CNRS)
Thierry Mora
(Ecole Normale Superieure)
Melody Shahsavarian
(Sanofi)
To address this challenge, we present a computational method grounded on sequence similarity, aimed at identifying statistically significant responsive BCRs. This method leverages well-known characteristics of affinity maturation and expected diversity. We validate its effectiveness using longitudinally sampled human immune repertoire data following influenza vaccination. The outcomes of this method hold promise for application in vaccine development, personalized medicine, and antibody-derived therapeutics.
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