Bulletin of the American Physical Society
2024 APS March Meeting
Monday–Friday, March 4–8, 2024; Minneapolis & Virtual
Session N37: Microbial Communities II
11:30 AM–2:18 PM,
Wednesday, March 6, 2024
Room: 103C
Sponsoring
Unit:
DBIO
Chair: Arthur Prindle, Northwestern University
Abstract: N37.00006 : Creating multi-antibiofilm therapeutics with cellulase based carbon dots*
12:30 PM–12:42 PM
Presenter:
Vikram Sawant
(Texas Tech University)
Authors:
Gordon Christopher
(Texas Tech University)
Vikram Sawant
(Texas Tech University)
Dimitri Pappas
(Texas Tech University)
Hamed F Dari-Sarraf
(Texas Tech University)
Carbon dots are synthesized from both cellulase and citric acid using a one-step hydrothermal carbonization method, and then characterized for surface properties, size, roughness, compositions, and emission spectra. P. aeruginosa biofilms were grown in a microfluidic environment for 24 hours and then treated with these carbon dots at a range of concentrations. Using microrheology, it was seen that biofilms treated with the cellulase based carbon dots were more viscous and less stiff compared to those treated with citric acid-based carbon dots. This appears to be because the cellulase carbon dots impact PSL within the biofilm based on microrheology studies examining bacteria strains with specific EPS component removed. This is consistent with the impact of molecular cellulase on biofilms. The penetration of the carbon dots into the biofilms is being examined via confocal microscopy. In general, initial studies suggest that the cellulase based carbon dots have the potential to act as an excellent multi-antibiofilm therapeutic in the future.
*Dr. Christopher gratefully acknowledge support from DOE/NNSA MSIPP Growing STEMS grant number DOE NA0003988 and Dr. Betsy Snell, Program Manager.
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