Bulletin of the American Physical Society
APS March Meeting 2024
Monday–Friday, March 4–8, 2024; Minneapolis & Virtual
Session N00: Poster Session II (11:30am-2:30pm CST)
11:30 AM,
Wednesday, March 6, 2024
Room: Hall BC
Sponsoring
Unit:
APS/SPS
Abstract: N00.00333 : Biomechanical activation and subcellular force adaptation in the peripheral mechanosensory system*
Presenter:
Stephen L Holtz
(Harvard Medical School)
Authors:
Stephen L Holtz
(Harvard Medical School)
Rachel I Wilson
(Harvard Medical School)
To overcome this limitation, we established approaches in the fruit fly antennal mechanosensory organ for recording mechanosensor mechanics and neural responses in situ. Mechanical stimuli drive the antenna to rotate, in turn activating its 200 mechanosensors. By precisely manipulating antennal position, we can simultaneously stimulate all antennal mechanosensors. Using laser microdissection to expose the organ, we can track cellular structures with 2-photon microscopy to understand force transmission into mechanosensors, and record single-neuron activity with patch-clamp electrophysiology to understand neural tuning to these forces. This has enabled both understanding of organ-level mechanical function, and, with genetic approaches, dissection of molecular contributions to mechanosensory responses.
*HHMI, NSF GRFP, NIH 5F31 NS106982, NIH R01 NS101157
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