Bulletin of the American Physical Society
APS March Meeting 2024
Monday–Friday, March 4–8, 2024; Minneapolis & Virtual
Session N00: Poster Session II (11:30am-2:30pm CST)
11:30 AM,
Wednesday, March 6, 2024
Room: Hall BC
Sponsoring
Unit:
APS/SPS
Abstract: N00.00319 : 13C NMR Investigation of the Metabolic Effects of Lanthanides in Neuroblastoma Cells*
Presenter:
Cody Larsen
(University of Texas at Dallas)
Author:
Cody Larsen
(University of Texas at Dallas)
This research investigates the influence of both lanthanide and paramagnetic transition metal ions on glucose metabolism and lactate production through the glycolytic pathway in cultured neuroblastoma cancer cells. Different metals were introduced to neuroblastoma cells, and their impacts on metabolism and cell proliferation were observed. To assess metabolic pathways, 13C NMR spectroscopy was employed to track the conversion of glucose into lactate over a 48-hour period, using a Bruker 600 MHz NMR spectrometer. CCK-8 toxicity assays and fluorescence viability tests were conducted to optimize the administered metal concentration.
The high paramagnetic properties of several of these compounds resulted in significant NMR spectrum broadening, and ongoing experiments are exploring counter-anion precipitation as a potential solution to this challenge. Nevertheless, preliminary findings indicate that some of these compounds have the potential to affect glycolytic metabolism in neuroblastoma cells, resulting in both the inhibition and stimulation of specific lactate products.
*This study was supported by the Welch Foundation grant AT‐2111‐20220331 and the US Department of Defense CDMRP grants W81XWH-21-1-0176, W81XWH-22-1-0105, W81XWH-19-1-0741, HT9425-23-1-0062, and W81XWH-22-1-0003.
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