Bulletin of the American Physical Society
APS March Meeting 2024
Monday–Friday, March 4–8, 2024; Minneapolis & Virtual
Session N00: Poster Session II (11:30am-2:30pm CST)
11:30 AM,
Wednesday, March 6, 2024
Room: Hall BC
Sponsoring
Unit:
APS/SPS
Abstract: N00.00316 : Effect of lithium isotopes on sodium/lithium/calcium exchanger in mitochondria*
Presenter:
Irina Bukhteeva
(University of Waterloo)
Authors:
Irina Bukhteeva
(University of Waterloo)
Fasih A Rahman
(University of Waterloo)
Brian Kendall
(University of Waterloo)
Robin Duncan
(University of Waterloo)
Joe Quadrilatero
(University of Waterloo)
Evgeny Pavlov
(New York University)
Michel J Gingras
(University of Waterloo)
Zoya Leonenko
(University of Waterloo)
Collaborations:
K. H. D. De Silva, J. D. Livingstone
Two methods were employed to assess Li isotope transport through NCLX: (i) calcium-induced fluorescence to monitor Ca2+ efflux dynamics and (ii) inductively coupled plasma mass spectrometry (ICP-MS).
Results indicated differences in calcium dynamics with functional NCLX when exposed to Li, Na, or K. However, when examining Li isotopes, no significant distinctions were observed in their partitioning within heart mitochondria or their impact on Ca2+ efflux. These findings suggest that either there is no distinct Li isotope effect on NCLX or that NCLX is not the sole molecular target for Li ions in mitochondria.
*IONIS Pharmaceutical and NFRF Exploration Grant (ZL and MG)WIN Nanofellowship (IB)
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