Bulletin of the American Physical Society
APS March Meeting 2024
Monday–Friday, March 4–8, 2024; Minneapolis & Virtual
Session N00: Poster Session II (11:30am-2:30pm CST)
11:30 AM,
Wednesday, March 6, 2024
Room: Hall BC
Sponsoring
Unit:
APS/SPS
Abstract: N00.00287 : Geometric Control of Cytoplasmic Streaming in the Drosophila Oocyte*
Presenter:
Olenka Jain
(Princeton University)
Authors:
Olenka Jain
(Princeton University)
Michael J Shelley
(Flatiron Institute (Simons Foundation))
Stanislav Y Shvartsman
(Princeton University)
Brato Chakrabarti
(Flatiron Institute)
Reza Farhadifar
(Flatiron Institute)
This work uses novel experimental techniques to show a geometric dependence on flow direction in late-stage oocytes. The experiments are supplemented with simulations that confirm the role of geometry in breaking the symmetry of the system and setting a direction for the flow. The simulations suggest that MT elastic energy minimization under motor-protein load may help choose the observed flow orientation around the axis of an ellipsoidal cell. The orientation of the flow has biological consequences for transport and mixing, which are critical for healthy oocyte development.
*Princeton UniversityFlatiron InstituteThis material is based upon work supported by the National Science Foundation Graduate Research Fellowship
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