Bulletin of the American Physical Society
APS March Meeting 2024
Monday–Friday, March 4–8, 2024; Minneapolis & Virtual
Session K30: Quantum Sensing and Information Processing for Biomedical ApplicationsIndustry Invited Undergrad Friendly
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Sponsoring Units: FIAP DBIO Chair: Wenjuan Zhu, University of Illinois at Urbana-Champaign Room: 102AB |
Tuesday, March 5, 2024 3:00PM - 3:36PM |
K30.00001: Photon Counting Detection and Phase Imaging For Multi-Contrast Deep Bioimaging Invited Speaker: Mini Das High-energy X-ray photons offer unique possibilities in detection, sensing and imaging for a range of applications, including biomedical, materials, defense/security and astronomy. However, engineering novel imaging systems that operate with small X-ray wavelengths can be challenging. Traditional X-ray imaging, while allowing deep penetration, lacks the ability for classify materials of similar X-ray absorption properties (like between cancer and normal tissue or separating plastics from bomb). Our goal is to develop methods that benefits from deep penetration and high resolution potential of X-rays but with accessible, cost effective X-ray sources (unlike in synchrotrons)for widespread applications. I will describe methods that involve extracting information from wave nature of X-rays with novel imaging system designs to generate additional contrast types. Emerging single-photon counting detectors can offer both the benefit of material classification via "color X-ray Imaging" but also yield spectral phase retrieval methods. My group has shown that along with innovative instrumentation, understanding and developing new light transport models for new imaging geometries can allow low-dose imaging designs and phase retrieval methods. I will present a latest example of single-mask X-ray phase imaging that yields differential X-ray phase imaging in a single shot. These new imaging signatures such as differential phase contrast with high resolution can open new avenues for imaging cancer, biomaterials, geophysical applications, defense and security. Time permitting, I will discuss potential to transfer some of these innovations to other modalities like optical and electron microscopy. |
Tuesday, March 5, 2024 3:36PM - 4:12PM |
K30.00002: Visualuzing and actuating biology with living magnetic contrast Invited Speaker: Christopher Contag Biomineralization of iron by magnetotactic bacteria leads to living cells with integrated magnetic signals that can be imaged by magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). We have been developing these bacteria as magnetoendosymbionts, to live in the cytoplasm of mammalian cells and exert desired effects with magnetothermal energy as an actuator of biological change. As living magnetic cells, they can be engineered to contain genes with thermosensitive genetic elements such that gene expression can be controlled with changes in temperature. This forms the foundation for controlling the fates and function of mammalian cells with magnetothermal control of cellular programs. This will enable noninvasive guided tissue regeneration to direct the replacement of lost or damaged cells, tissues and organs with image guidance. |
Tuesday, March 5, 2024 4:12PM - 4:48PM |
K30.00003: Non-linear organic fluorophores for detecting transmembrane protein aggregation Invited Speaker: Andrea M Armani From multi-photon to single molecule, the past several decades have witnessed a revolution in fluorescent microscopy. These techniques have revealed the inner working of cells and tissue and have relied on symbiotic advances in advanced molecular probes, light emitting molecules and particles, and novel instrumentation. Building on these developments, researchers began to develop functional nanomaterials or materials that can response to their environment and serve as nano-sensors. One of the first such molecules reported electric fields, allowing neuron signaling to be observed. However, the optical signal generated by voltage reporters is often low and the temporal response is orders of magnitude slower than the signal of interest, placing limitations on the measurements that can be performed. Thus, material scientists and chemists began to pursue the development of alternative systems. In parallel, the fields of organic solar cells and integrated photonics were actively pursuing the design of materials with similar photo-responsive properties, thus forming a foundation for improved functional organic imaging agents. In this talk, I will discuss some of our recent work in developing functional imaging agents for multi-wavelength and multi-photon live-cell imaging, focusing on recent molecular designs performed using density functional theory as well as in vitro studies. |
Tuesday, March 5, 2024 4:48PM - 5:24PM |
K30.00004: 6D Single-Molecule Orientation-Localization Microscopy: Fundamental Limits for Visualizing the Dynamic Organization of Biomolecule Invited Speaker: Matthew D Lew Fluorescent molecules are uniquely versatile quantum emitters whose emissive properties can be exquisitely sensitive to the surrounding environment. The position, wavevector, polarization, and wavelength of each photon collected from a single fluorophore can yield detailed information on the nanoscale organization and structure of biomolecular assemblies, but imaging systems must be carefully designed to encode this information efficiently into the images captured by a camera. Here, I will introduce the concept of 6D single-molecule orientation-localization microscopy (SMOLM), in which the dipole-spread function (the image of a dipole-like emitter) is specifically engineered to enable sensitive measurements of the 3D position and 3D orientation of any fluorescent emitter. I will show how classical and quantum estimation theories reveal the fundamental best-possible limits of accurately and precisely measuring molecular orientation and dynamic rotation. I will also discuss how to engineer imaging systems whose performance approaches these limits in practical experiments. Finally, I will cover recent work in my lab on how single fluorogenic molecules can be used to sense protein architectures within biological targets without the need for genetic or covalent modifications of the proteins themselves. We use fluorogenic dyes like Nile red and merocyanine 540 to image the helical organization of peptide assemblies and the network architecture of proteins within biomolecular condensates. |
Tuesday, March 5, 2024 5:24PM - 6:00PM |
K30.00005: Computational Imaging through Scatter using Synthetic Waves Invited Speaker: Florian Willomitzer Imaging through scattering scenes or materials severely limits the visual acuity of optical imaging systems. This talk discusses how diversity in illumination wavelength can be utilized to circumvent the problem of phase randomization in scattered light fields. Our technique probes the scene at two closely spaced optical wavelengths and computationally assembles a complex "synthetic field" at a "synthetic wavelength," which is used for further processing. As the synthetic wavelength is the beat wavelength of the two used optical "carrier" wavelengths, it can be picked orders of magnitudes larger, and the computationally assembled synthetic field becomes immune to scatter. Amongst other applications, the introduced method allows for holographic measurements of hidden objects through scattering media or around corners, or for interferometric measurements of macroscopic objects with rough surfaces. During the talk, different flavors of the technique will be introduced, including a method to retrieve the complex synthetic field in single-shot. |
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