Similarity analysis for Serotonin Receptor Networks*

Serotonin 5-HT receptors are pivotal for regulating virtually all cerebral functions. Imbalances in serotonin levels within the organism are linked to behavioral and neurological disorders. Understanding how 5-HT receptors contribute to normal brain function is paramount in developing more accurate treatments for conditions such as depression. This study investigates the similarity of complex networks involving 5-HT receptors and serotonin transporters, a vital protein in managing psychiatric disorders. We applied the Jaccard similarity coefficient to measure the similarity of complex networks that map 5-HT receptors and Serotonin Transporters. Our results suggest that the similarity between the networks of 5-HT receptors and serotonin transporters may support the development of methods and drugs capable of reversing pathologies associated with serotonin imbalance in the human body.