Bulletin of the American Physical Society
APS March Meeting 2024
Monday–Friday, March 4–8, 2024; Minneapolis & Virtual
Session BB02: V: Biological Physics at the Molecular Scale
11:30 AM–12:42 PM,
Monday, March 4, 2024
Room: Virtual Room 02
Sponsoring
Unit:
DBIO
Chair: Yin-Ting Yeh, National Institute of Standards and Technology
Abstract: BB02.00005 : Infrared probes of ion specificity in signaling metalloproteins and model ion-binding compounds*
12:18 PM–12:30 PM
Presenter:
Sean C Edington
(University of New Hampshire)
Authors:
Sean C Edington
(University of New Hampshire)
Emily Armlin
(University of New Hampshire)
Diotima Bose
(University of New Hampshire)
Sara Forcina
(University of New Hampshire)
Kira Gusciora
(University of New Hampshire)
Harrison Vedrani
(University of New Hampshire)
Ion-sensing proteins play critical and varied roles in hundreds of biological signaling pathways that are essential to human health and implicated in diseases ranging from cardiac arrhythmia to cancer. Central to the function of these biomolecules are compact ion recognition domains that drive global structural reconfiguration in response to local binding events and that are capable of discriminating between chemically similar ions. This discriminatory power has recently been exploited to achieve efficient separation of technologically essential rare-earth elements and relies on finely-tuned electrostatic, thermodynamic, and kinetic properties that remain incompletely understood.
We mobilize infrared spectroscopy as a physical probe of binding site interactions and structure in a variety of signaling metalloproteins and small ion-binding compounds. The latter are used to model the spectroscopic properties of much larger biomolecules. Our results show how the infrared spectrum reports on proteins with different ion binding modes and affinities and, similarly, on the binding configurations of small molecules that are structurally similar but exhibit large differences in ion specificity. These measurements help inform further study of the structural and biophysical consequences of modification to biological and bio-inspired ion-binding structures.
*This work was supported by a startup grant from the University of New Hampshire's College of LIfe Sciences and Agriculture.
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