Bulletin of the American Physical Society
APS March Meeting 2023
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session W16: Flow and Structure in Multiphase Systems
3:00 PM–6:00 PM,
Thursday, March 9, 2023
Room: Room 208
Sponsoring
Unit:
DSOFT
Chair: Saurabh Nath, Massachusetts Institute of Technology
Abstract: W16.00015 : Multi-scale characterization of hydrogels of biological interest*
5:48 PM–6:00 PM
Presenter:
SOUHAILA N'MAR
(Université Paris Saclay)
Authors:
SOUHAILA N'MAR
(Université Paris Saclay)
Ludovic Pauchard
(Université Paris Saclay)
Frédérique Giorgiutti-Dauphiné
(Université Paris saclay)
Patrick Guenoun
(CEA SACLAY)
Jean-Philippe Renault
(CEA SACLAY)
We study here the way to form a homogeneous bead of colloidal hydrogel. We control the gelation kinetics of silica nanoparticles as well as the drying. This process leads to the formation of a gel with well-defined mechanical properties and permeability. A phase diagram evidences two regions in the parameter plane, i.e. the physicochemical properties versus the evaporation rate: a region where the drop undergoes an isotropic shrinkage and forms an homogeneous gel and a region where mechanical instabilities (cracking, buckling) appear. We proceed to a multiscale analysis from the microscopic scale by studying the structure of silica gels (X-ray scattering) to the macroscopic scale through mechanical properties measurements (indentation testing).
Finally, we have shown that the addition of a model protein (Bovine Serum Albumine) in the hydrogel bead, results in the reinforcement of the structure, involving a controlled deformability. Such a process has potential applications in drug delivery
*Labex Palm and ANR 'BOGUS'
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