Bulletin of the American Physical Society
APS March Meeting 2023
Volume 68, Number 3
Las Vegas, Nevada (March 5-10)
Virtual (March 20-22); Time Zone: Pacific Time
Session W06: Bacterial Communities II
3:00 PM–5:48 PM,
Thursday, March 9, 2023
Room: Room 129
Sponsoring
Unit:
DBIO
Chair: Jay Tang, Brown University
Abstract: W06.00006 : Mechanics and microstructure in biofilms and their interactions with the immune system: Why you should care, and why I think this intersection is understudied.*
4:24 PM–4:36 PM
Presenter:
Vernita Gordon
(University of Texas at Austin)
Authors:
Vernita Gordon
(University of Texas at Austin)
Gordon Christopher
(Texas Tech University)
Kendra P Rumbaugh
(Texas Tech University Health Sciences Center)
We have recently found, for one important biofilm-forming human pathogen (Pseudomonas aeruginosa) growing in chronic wounds, that the biofilm's matrix composition, mechanical properties, and microstructure are sensitively dependent on both bacterial-produced matrix materials and on factors arising from growth inside an animal host, as are the efficacy of matrix-compromizing enzymatic treatments. We have also found that the success of neutrophils at engulfing constituents from a biofilm or similar target depend on the biofilm's viscoelasticity and microstructure. How these myriad parameters interplay in real-world infections, which are polymicrobial and can happen at many different anatomical sites, is not understood at all. In this talk, I will give a synthetic overview of our findings and how they point toward future investigation.
*NIH R01AI121500
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